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Article

BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention.

Neurology - 30 May 2017

Boots Elizabeth A, Schultz Stephanie A, Clark Lindsay R, Racine Annie M, Darst Burcu F, Koscik Rebecca L, Carlsson Cynthia M, Gallagher Catherine L, Hogan Kirk J, Bendlin Barbara B, Asthana Sanjay, Sager Mark A, Hermann Bruce P, Christian Bradley T, Dubal Dena B, Engelman Corinne D, Johnson Sterling C, Okonkwo Ozioma C

Abstract excerpt

OBJECTIVE: To examine the influence of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on longitudinal cognitive trajectories in a large, cognitively healthy cohort enriched for Alzheimer disease (AD) risk and to understand whether β-amyloid (Aβ) burden plays a moderating role in this relationship. METHODS: One thousand twenty-three adults (baseline age 54.94 ± 6.41 years) enrolled in the...

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Source

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Identifiers

PMID: 28468845
DOI: 10.1212/WNL.0000000000003980
PMCID: PMC5447398

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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