Article
BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF.
International psychogeriatrics - 1 Nov 2017
Lim Yen Ying, Rainey-Smith Stephanie, Lim Yoon, Laws Simon M, Gupta Veer, Porter Tenielle, Bourgeat Pierrick, Ames David, Fowler Christopher, Salvado Olivier, Villemagne Victor L, Rowe Christopher C, Masters Colin L, Zhou Xin Fu, Martins Ralph N, Maruff Paul
Abstract excerpt
BACKGROUND: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism Met allele exacerbates amyloid (Aβ) related decline in episodic memory (EM) and hippocampal volume (HV) over 36-54 months in preclinical Alzheimer's disease (AD). However, the extent to which Aβ+ and BDNF Val66Met is related to circulating markers of BDNF (e.g. serum) is unknown. We aimed to determine the effect of Aβ and the BDNF...
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