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Article

Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jun 2006

Gewirtz Andrew T, Vijay-Kumar Matam, Brant Steven R, Duerr Richard H, Nicolae Dan L, Cho Judy H

Abstract excerpt

Crohn's disease (CD) is associated with elevated adaptive immunity to commensal microbes, with flagellin being a dominant antigen. In light of heightened awareness of the importance of innate immunity in regulating adaptive immunity and ambiguity as to the role of CD-associated immune responses in CD pathophysiology, we sought to determine whether natural acquisition of immune responses to flagellin were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Dominant

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Share to Inflammatory Bowel Diseases

Share to Toll-Like Receptor 5

Source

Identifiers

PMID: 16439468
DOI: 10.1152/ajpgi.00544.2005

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease.PMID 16439468Read ↗

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A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.Semantic proximity Read ↗

Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.Semantic proximity Read ↗

A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin.Semantic proximity Read ↗

Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5Semantic proximity Read ↗

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Human gut flagellome profiling using FlaPro reveals TLR5-related phenotype-specific alterations in IBD.Semantic proximity Read ↗

Convergent Losses of TLR5 Suggest Altered Extracellular Flagellin Detection in Four Mammalian LineagesSemantic proximity Read ↗

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