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Article

COMT and STH polymorphisms interaction on cognition in schizophrenia.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Feb 2015

Bosia Marta, Pigoni Alessandro, Pirovano Adele, Lorenzi Cristina, Spangaro Marco, Buonocore Mariachiara, Bechi Margherita, Cocchi Federica, Guglielmino Carmelo, Bramanti Placido, Smeraldi Enrico, Cavallaro Roberto

Abstract excerpt

Catechol-O-methyltransferase (COMT) gene, a key regulator of prefrontal cortex (PFC) dopamine (DA) availability, has been extensively studied in relation to cognitive domains, mainly executive functions, that are impaired in schizophrenia, but results are still controversial. Since recent studies in patients affected by neurodegenerative and psychiatric disorders suggested a role of saitohin (STH) gene as a...

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Identifiers

PMID: 25283873
DOI: 10.1007/s10072-014-1936-9

Genes

STH
COMT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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