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Using Engineered <i>Escherichia coli</i> to Synthesize Squalene with Optimized Manipulation of Squalene Synthase and Mevalonate Pathway

2020-10-29

Abstract excerpt

Squalene is the metabolic precursor of sterols and naturally synthesized in the deep-dea shark liver and human sebum. The utilization of squalene is wide such as food, cosmetical, and pharmaceutical industries. This experiment used engineered Escherichia coli to construct the gene circuit for the biosynthesis of squalene. Human squalene synthase (hSQS) efficiently catalyzes the synthesis of squalene. Also, mevalon...

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Literature Corpus work
576268fb-dc08-52a7-8ea1-1c45bc5059e8
DOI
10.1101/2020.10.28.360032
Open publication

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Using Engineered <i>Escherichia coli</i> to Synthesize Squalene with Optimized Manipulation of Squalene Synthase and Mevalonate PathwayDOI 10.1101/2020.10.28.360032
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