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Article

Mapping a kingdom-specific functional domain of squalene synthase.

Biochimica et biophysica acta - 1 Sept 2016

Linscott Kristin B, Niehaus Thomas D, Zhuang Xun, Bell Stephen A, Chappell Joe

Abstract excerpt

Squalene synthase catalyzes the first committed step in sterol biosynthesis and consists of both an amino-terminal catalytic domain and a carboxy-terminal domain tethering the enzyme to the ER membrane. While the overall architecture of this enzyme is identical in eukaryotes, it was previously shown that plant and animal genes cannot complement a squalene synthase knockout mutation in yeast unless the...

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PMID: 27320012
DOI: 10.1016/j.bbalip.2016.06.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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