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Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast.

Metabolic engineering - 1 Jul 2020

Hu Tianyuan, Zhou Jiawei, Tong Yuru, Su Ping, Li Xinlin, Liu Yuan, Liu Nan, Wu Xiaoyi, Zhang Yifeng, Wang Jiadian, Gao Linhui, Tu Lichan, Lu Yun, Jiang Zhouqian, Zhou Yongjin J, Gao Wei, Huang Luqi

Abstract excerpt

Miltiradiene is a key intermediate in the biosynthesis of many important natural diterpene compounds with significant pharmacological activity, including triptolide, tanshinones, carnosic acid and carnosol. Sufficient accumulation of miltiradiene is vital for the production of these medicinal compounds. In this study, comprehensive engineering strategies were applied to construct a high-yielding miltiradiene...

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Biosynthetic Pathways
CRISPR-Cas Systems
Diterpenes
Fermentation
Metabolic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolic Networks and Pathways

Mutant Chimeric Proteins

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PMID: 32268192
DOI: 10.1016/j.ymben.2020.03.011

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