Enhance production of diterpenoids in yeast by overexpression of the fused enzyme of ERG20 and its mutant mERG20.

doi:10.1016/j.jbiotec.2019.10.019

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Article

Enhance production of diterpenoids in yeast by overexpression of the fused enzyme of ERG20 and its mutant mERG20.

Journal of biotechnology - 10 Jan 2020

Dong Hua, Chen Shan, Zhu Jianxun, Gao Ke, Zha Wenlong, Lin Pengcheng, Zi Jiachen

Abstract excerpt

Yeast has been widely used for large-scale production of terpenoids. In yeast, modifications of terpenoid biosynthetic pathways have been intensively studied. tHMG1 (encoding the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase of yeast) and UPC2-1 (the G888D mutant of UPC2 encoding a transcription factor) were integrated into yeast chromosome, and ERG9 (the squalene synthase gene of yeast) was...

Topics

Amino Acid Substitution
Biosynthetic Pathways
Dimethylallyltranstransferase
Diterpenes
Gene Expression
Gene Fusion
Geranyltranstransferase
Metabolic Engineering
Mutation
Polyisoprenyl Phosphates
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Terpenes

Source

Open in PubMed

Identifiers

PMID: 31689467
DOI: 10.1016/j.jbiotec.2019.10.019

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