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Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers.

Chemical research in toxicology - 19 Mar 2018

Murphy Sharon E, von Weymarn Linda B, Parenteau Marc, Stepanov Irina, Tiirikainen Maarit, LeMarchand Loic, Park Sungshim L

Abstract excerpt

At similar smoking levels, African American's lung cancer risk is as much as twice that of whites. We hypothesized that racial/ethnic differences in UDP-glucuronosyltransferase (UGT)-catalyzed glucuronidation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a detoxication pathway for the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) may contribute to this variable...

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Identifiers

PMID: 29460622
DOI: 10.1021/acs.chemrestox.7b00264
PMCID: PMC6058729

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