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Article

DNA ligase-based strategy for quantifying heterogeneous DNA methylation without sequencing.

Clinical chemistry - 1 Jan 2015

Wee Eugene J H, Rauf Sakandar, Shiddiky Muhammad J A, Dobrovic Alexander, Trau Matt

Abstract excerpt

BACKGROUND: DNA methylation is a potential source of disease biomarkers. Typically, methylation levels are measured at individual cytosine/guanine (CpG) sites or over a short region of interest. However, regions of interest often show heterogeneous methylation comprising multiple patterns of methylation (epialleles) on individual DNA strands. Heterogeneous methylation is largely ignored because digital methods...

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Share to CpG Islands
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

Share to Epigenesis, Genetic

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Identifiers

PMID: 25274555
DOI: 10.1373/clinchem.2014.227546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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