Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Development in ligase-mediated techniques for bio-molecular analysis].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 Mar 2009

Xu Chao, Zhou Yafeng, Zhang Xian'en

Abstract excerpt

Two oligonucleotide probes are permitted to anneal to the nucleic acid target of interest so that the ends of two probes immediately become adjacent to each other. The ligase can then efficiently join the two juxtaposed oligonucleotide probes by the formation of a phosphodiester bond if and only if perfectly matched base-pairs at the nick are present. During past 20 years, many ligase-mediated techniques have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to DNA Methylation
Share to Ligases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Probe Techniques

Share to Mutation

Share to Oligonucleotide Probes

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 19621570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Development in ligase-mediated techniques for bio-molecular analysis].PMID 19621570Read ↗

Advances in ligase-based nucleic acid amplification technology for detecting gene mutations: a review.Semantic proximity Read ↗

Enhanced detection and distinction of RNA by enzymatic probe ligation.Semantic proximity Read ↗

Highly-efficient T4 DNA ligase-based SNP analysis using a ligation fragment containing a modified nucleobase at the end.Semantic proximity Read ↗

Controllable Mismatched Ligation for Bioluminescence Screening of Known and Unknown Mutations.Semantic proximity Read ↗

Detection of single-base mutation in RNA using T4 RNA ligase-based nick-joining or DNAzyme-based nick-generation.Semantic proximity Read ↗

Ligase chain reaction coupled with rolling circle amplification for high sensitivity detection of single nucleotide polymorphisms.Semantic proximity Read ↗

Ligation-mediated rolling-circle amplification-based approaches to single nucleotide polymorphism detection.Semantic proximity Read ↗

Enhanced discrimination of single nucleotide polymorphisms using 3' nucleotide differences in ligase detection reaction probes.Semantic proximity Read ↗

A multiplex single nucleotide polymorphism genotyping method using ligase-based mismatch discrimination and CE-SSCP.Semantic proximity Read ↗

Advances in ligase chain reaction and ligation-based amplifications for genotyping assays: Detection and applications.Semantic proximity Read ↗

Genotyping by ligation assays.Semantic proximity Read ↗

Mammalian DNA ligases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.