Article
Epiallele quantification using molecular inversion probes.
Analytical chemistry - 1 Apr 2011
Palanisamy Ramkumar, Connolly Ashley R, Trau Matt
Abstract excerpt
The location and level of DNA methylation within a genome is emerging as an important biomarker for cancer diagnosis. Despite its potential, it is difficult to comprehensively analyze the epialleles that are often found in a biological sample. Therefore, an assay utilizing molecular inversion probes was designed and used to expose and quantify epialleles in heterogeneously methylated bisulphite treated genomic...
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