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Article

High-throughput DNA methylation profiling using universal bead arrays.

Genome research - 1 Mar 2006

Bibikova Marina, Lin Zhenwu, Zhou Lixin, Chudin Eugene, Garcia Eliza Wickham, Wu Bonnie, Doucet Dennis, Thomas Neal J, Wang Yunhua, Vollmer Ekkehard, Goldmann Torsten, Seifart Carola, Jiang Wei, Barker David L, Chee Mark S, Floros Joanna, Fan Jian-Bing

Abstract excerpt

We have developed a high-throughput method for analyzing the methylation status of hundreds of preselected genes simultaneously and have applied it to the discovery of methylation signatures that distinguish normal from cancer tissue samples. Through an adaptation of the GoldenGate genotyping assay implemented on a BeadArray platform, the methylation state of 1536 specific CpG sites in 371 genes (one to nine CpG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16449502
DOI: 10.1101/gr.4410706
PMCID: PMC1415217

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