Article
Comparison of three targeted enrichment strategies on the SOLiD sequencing platform.
PloS one - 29 Apr 2011
Hedges Dale J, Guettouche Toumy, Yang Shan, Bademci Guney, Diaz Ashley, Andersen Ashley, Hulme William F, Linker Sara, Mehta Arpit, Edwards Yvonne J K, Beecham Gary W, Martin Eden R, Pericak-Vance Margaret A, Zuchner Stephan, Vance Jeffery M, Gilbert John R
Abstract excerpt
Despite the ever-increasing throughput and steadily decreasing cost of next generation sequencing (NGS), whole genome sequencing of humans is still not a viable option for the majority of genetics laboratories. This is particularly true in the case of complex disease studies, where large sample sets are often required to achieve adequate statistical power. To fully leverage the potential of NGS technology on...
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