Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence.

Psychopharmacology - 1 Apr 2015

Bidwell L C, McGeary J E, Gray J C, Palmer R H C, Knopik V S, MacKillop J

Abstract excerpt

RATIONALE: Nicotine dependence (ND) is a heterogeneous phenotype with complex genetic influences. The use of intermediate ND phenotypes may clarify genetic influences and reveal specific etiological pathways. Prior work has found that the four Primary Dependence Motives (PDM) subscales (Automaticity, Craving, Loss of Control, and Tolerance) of the Wisconsin Inventory of Smoking Motives (WISDM) represent heavy,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD56 Antigen
Share to Motivation
Share to Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proteins

Share to Receptors, Dopamine D2

Share to Smoking

Share to Tobacco Use Disorder

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 25273375
DOI: 10.1007/s00213-014-3748-2
PMCID: PMC4361268

Genes

DRD2
NCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence.PMID 25273375Read ↗

An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans.Semantic proximity Read ↗

Refining the tobacco dependence phenotype using the Wisconsin Inventory of Smoking Dependence Motives.Semantic proximity Read ↗

Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.Semantic proximity Read ↗

Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.Semantic proximity Read ↗

Dissection of the phenotypic and genotypic associations with nicotinic dependence.Semantic proximity Read ↗

Genome-wide single nucleotide polymorphism heritability of nicotine dependence as a multidimensional phenotype.Semantic proximity Read ↗

Phenotypic and genetic factors in motives for smoking.Semantic proximity Read ↗

Genetic and Epigenetic Analysis Revealing Variants in the NCAM1-TTC12-ANKK1-DRD2 Cluster Associated Significantly With Nicotine Dependence in Chinese Han Smokers.Semantic proximity Read ↗

A prospective study of the effects of the DRD2/ANKK1 TaqIA polymorphism and impulsivity on smoking initiation.Semantic proximity Read ↗

Refining the tobacco dependence phenotype using the Wisconsin Inventory of Smoking Dependence Motives: II. Evidence from a laboratory self-administration assay.Semantic proximity Read ↗

Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.Semantic proximity Read ↗

Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.