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Article

Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.

Human molecular genetics - 15 Dec 2006

Gelernter Joel, Yu Yi, Weiss Roger, Brady Kathleen, Panhuysen Carolien, Yang Bao-Zhu, Kranzler Henry R, Farrer Lindsay

Abstract excerpt

Nicotine dependence (ND) is a moderately heritable trait. We ascertained a set of 1615 subjects in 632 families [319 African-American (AA) and 313 European-American (EA)] based on affected sibling pairs with cocaine or opioid dependence. Subjects were interviewed with the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Previously, we identified a modest linkage peak (LOD score =1.97) for...

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Source

Identifiers

PMID: 17085484
DOI: 10.1093/hmg/ddl426

Genes

DRD2
NCAM1

Provenance

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Related research

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Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.PMID 17085484Read ↗

Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.Semantic proximity Read ↗

Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.Semantic proximity Read ↗

Genetic and Epigenetic Analysis Revealing Variants in the NCAM1-TTC12-ANKK1-DRD2 Cluster Associated Significantly With Nicotine Dependence in Chinese Han Smokers.Semantic proximity Read ↗

Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample.Semantic proximity Read ↗

Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions.Semantic proximity Read ↗

Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.Semantic proximity Read ↗

A DRD2 and ANKK1 haplotype is associated with nicotine dependence.Semantic proximity Read ↗

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