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Article

Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.

Alcoholism, clinical and experimental research - 1 Dec 2008

Yang Bao-Zhu, Kranzler Henry R, Zhao Hongyu, Gruen Jeffrey R, Luo Xingguang, Gelernter Joel

Abstract excerpt

BACKGROUND: Each gene in the chromosome 11q23 cluster of NCAM1, TTC12, ANKK1, and DRD2 is functionally linked to dopamine in brain. Many association studies of DRD2 and substance dependence (SD), including alcohol dependence (AD) and drug dependence (DD), have been reported; the results have been...

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Source

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Identifiers

PMID: 18828801
DOI: 10.1111/j.1530-0277.2008.00800.x
PMCID: PMC2975565

Genes

DRD2
NCAM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18828801-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.PMID 18828801Read ↗

Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.Semantic proximity Read ↗

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Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions.Semantic proximity Read ↗

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