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Article

Pharmacogenetic aspects of the use of tacrolimus in renal transplantation: recent developments and ethnic considerations.

Expert opinion on drug metabolism & toxicology - 1 May 2016

Tang J T, Andrews L M, van Gelder T, Shi Y Y, van Schaik R H N, Wang L L, Hesselink D A

Abstract excerpt

INTRODUCTION: Tacrolimus (Tac) is effective in preventing acute rejection but has considerable toxicity and inter-individual variability in pharmacokinetics and pharmacodynamics. Part of this is explained by polymorphisms in genes encoding Tac-metabolizing enzymes and transporters. A better understanding of Tac pharmacokinetics and pharmacodynamics may help to minimize different outcomes amongst transplant...

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Source

Identifiers

PMID: 27010623
DOI: 10.1517/17425255.2016.1170808

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POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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