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Article

CYP3A5 and CYP3A4, but not ABCB1 polymorphisms affect tacrolimus dose-adjusted trough concentrations in kidney transplant recipients.

Pharmacogenomics - 1 Feb 2014

Kurzawski Mateusz, Dąbrowska Justyna, Dziewanowski Krzysztof, Domański Leszek, Perużyńska Magdalena, Droździk Marek

Abstract excerpt

BACKGROUND: Tacrolimus (TAC), acting as a calcineurin inhibitor, is an immunosuppressant widely used after kidney transplantation. TAC requires blood concentration monitoring due to large interindividual variability in its pharmacokinetics and a narrow therapeutic index. Since genetic factors are considered responsible for a part of the observed pharmacokinetic variability, hereby SNPs within the CYP3A4, CYP3A5...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Cytochrome P-450 CYP3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ABCB1 gene

Share to Immunosuppression Therapy

Share to Kidney Transplantation

Share to Polymorphism, Single Nucleotide

Share to Renal Transplantation Outcomes and Treatments

Share to Tacrolimus

Source

Identifiers

PMID: 24444408
DOI: 10.2217/pgs.13.199

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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CYP3A5 and CYP3A4, but not ABCB1 polymorphisms affect tacrolimus dose-adjusted trough concentrations in kidney transplant recipients.PMID 24444408Read ↗

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