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Article

Genetic polymorphisms and individualized tacrolimus dosing.

Transplantation proceedings - 1 Oct 2010

López-Montenegro Soria M A, Kanter Berga J, Beltrán Catalán S, Milara Payá J, Pallardó Mateu L M, Jiménez Torres N V

Abstract excerpt

BACKGROUND: Genetic polymorphisms of metabolism enzymes or intestinal drug transporters may affect pharmacokinetic responses to immunosuppressive drugs in renal transplant recipients. We sought to identify the frequency of genetic polymorphisms and their importance for individualization of tacrolimus doses. PATIENTS AND METHODS: We performed an observational study in 35 renal transplant recipients treated with...

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Identifiers

PMID: 20970601
DOI: 10.1016/j.transproceed.2010.08.001

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