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Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes.

Clinical chemistry and laboratory medicine - 1 May 2011

Tavira Beatriz, Coto Eliecer, Garciá Eliecer Coto, Díaz-Corte Carmen, Ortega Francisco, Arias Manuel, Torres Armando, Díaz Juan M, Selgas Rafael, López-Larrea Carlos, Campistol Josep M, Alvarez Victoria, Alvarezca Victoria

Abstract excerpt

BACKGROUND: Tacrolimus (Tac) is an immunosuppressive drug used to prevent post-transplant (PT) organ rejection. Continuous Tac monitoring is necessary to adjust the dose and prevent toxicity or rejection. Tac is metabolized by cytochrome-P450 (CYP) enzymes, and variation at the CYP and other drug metabolizing enzymes could influence Tac bio-availability and dose requirements. Our aim was to define the effect of...

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Identifiers

PMID: 21480817
DOI: 10.1515/CCLM.2011.143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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