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Article

A novel rat model of Alzheimer's disease based on lentiviral-mediated expression of mutant APP.

Neuroscience - 22 Jan 2015

Parsi S, Pandamooz S, Heidari S, Naji M, Morfini G, Ahmadiani A, Dargahi L

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is characterized by progressive and irreversible cognitive and memory impairment. The discovery of familial forms of AD (fAD) in association with specific gene mutations facilitated the generation of numerous rodent models. These models in turn proved valuable for the study of molecular mechanisms underlying AD pathogenesis, and facilitated translational research and...

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Source

Identifiers

PMID: 25270904
DOI: 10.1016/j.neuroscience.2014.09.045

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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