Article
Allele-specific RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2009
Rodríguez-Lebrón Edgardo, Gouvion Cynthia M, Moore Steven A, Davidson Beverly L, Paulson Henry L
Abstract excerpt
Despite recent advances suggesting new therapeutic targets, Alzheimer's disease (AD) remains incurable. Aberrant production and accumulation of the Abeta peptide resulting from altered processing of the amyloid precursor protein (APP) is central to the pathogenesis of disease, particularly in dominantly inherited forms of AD. Thus, modulating the production of APP is a potential route to effective AD therapy....
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