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Article

Mouse models of Alzheimer's disease for preclinical research.

Neurochemistry international - 1 Sept 2022

Watamura Naoto, Sato Kaori, Saido Takaomi C

Abstract excerpt

Most mouse models for preclinical research into Alzheimer's disease (AD) rely on the overexpression paradigm, in which familial AD (FAD)-related genes linked to amyloid precursor protein (APP) and presenilin-1 (PSEN1) are overexpressed. Such mice have been used for over two decades as the first-generation transgenic lines for AD, with animals exhibiting AD pathologies along with additional phenotypes, leading to...

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PMID: 35618239
DOI: 10.1016/j.neuint.2022.105361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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