Article
Animal models of Alzheimer's disease: Applications, evaluation, and perspectives.
Zoological research - 18 Nov 2022
Chen Zhi-Ya, Zhang Yan
Abstract excerpt
Although great advances in elucidating the molecular basis and pathogenesis of Alzheimer's disease (AD) have been made and multifarious novel therapeutic approaches have been developed, AD remains an incurable disease. Evidence shows that AD neuropathology occurs decades before clinical presentation. AD is divided into three stages: preclinical stage, mild cognitive impairment (MCI), and AD dementia. In the...
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