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Article

Deciphering clonality in aneuploid breast tumors using SNP array and sequencing data.

Genome biology - 1 Oct 2014

Lönnstedt Ingrid M, Caramia Franco, Li Jason, Fumagalli Debora, Salgado Roberto, Rowan Andrew, Salm Max, Kanu Nnennaya, Savas Peter, Horswell Stuart, Gade Stephan, Loibl Sibylle, Neven Patrick, Sotiriou Christos, Swanton Charles, Loi Sherene, Speed Terence P

Abstract excerpt

Intra-tumor heterogeneity concerns the existence of genetically different subclones within the same tumor. Single sample quantification of heterogeneity relies on precise determination of chromosomal copy numbers throughout the genome, and an assessment of whether identified mutation variant allele fractions match clonal or subclonal copy numbers. We discuss these issues using data from SNP arrays, whole exome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25270265
DOI: 10.1186/s13059-014-0470-7
PMCID: PMC4220069

Genes

ERBB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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