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Article

Aneuploidy, TP53 mutation, and amplification of MYC correlate with increased intratumor heterogeneity and poor prognosis of breast cancer patients.

Genes, chromosomes & cancer - 1 Apr 2018

Oltmann Johanna, Heselmeyer-Haddad Kerstin, Hernandez Leanora S, Meyer Rüdiger, Torres Irianna, Hu Yue, Doberstein Natalie, Killian J Keith, Petersen David, Zhu Yuelin Jack, Edelman Daniel C, Meltzer Paul S, Schwartz Russell, Gertz E Michael, Schäffer Alejandro A, Auer Gert, Habermann Jens K, Ried Thomas

Abstract excerpt

The clinical course of breast cancer varies from one patient to another. Currently, the choice of therapy relies on clinical parameters and histological and molecular tumor features. Alas, these markers are informative in only a subset of patients. Therefore, additional predictors of disease outcome would be valuable for treatment stratification. Extensive studies showed that the degree of variation of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29181861
DOI: 10.1002/gcc.22515
PMCID: PMC5807164

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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