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Article

Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype.

The Journal of clinical investigation - 1 Feb 2010

Park So Yeon, Gönen Mithat, Kim Hee Jung, Michor Franziska, Polyak Kornelia

Abstract excerpt

Intratumor genetic heterogeneity is a key mechanism underlying tumor progression and therapeutic resistance. The prevailing model for explaining intratumor diversity, the clonal evolution model, has recently been challenged by proponents of the cancer stem cell hypothesis. To investigate this iss...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20101094
DOI: 10.1172/JCI40724
PMCID: PMC2810089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20101094-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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