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Article

Quantification of within-sample genetic heterogeneity from SNP-array data.

Scientific reports - 12 Jun 2017

Martinez Pierre, Kimberley Christopher, BirkBak Nicolai J, Marquard Andrea, Szallasi Zoltan, Graham Trevor A

Abstract excerpt

Intra-tumour genetic heterogeneity (ITH) fosters drug resistance and is a critical hurdle to clinical treatment. ITH can be well-measured using multi-region sampling but this is costly and challenging to implement. There is therefore a need for tools to estimate ITH in individual samples, using standard genomic data such as SNP-arrays, that could be implemented routinely. We designed two novel scores S and R,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28607403
DOI: 10.1038/s41598-017-03496-0
PMCID: PMC5468233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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