Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts.

doi:10.1093/carcin/bgu206

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Article

Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts.

Carcinogenesis - 1 Dec 2014

Perriaud Laury, Marcel Virginie, Sagne Charlotte, Favaudon Vincent, Guédin Aurore, De Rache Aurore, Guetta Corinne, Hamon Florian, Teulade-Fichou Marie-Paule, Hainaut Pierre, Mergny Jean-Louis, Hall Janet

Abstract excerpt

G-quadruplex (G4) structures in intron 3 of the p53 pre-mRNA modulate intron 2 splicing, altering the balance between the fully spliced p53 transcript (FSp53, encoding full-length p53) and an incompletely spliced transcript retaining intron 2 (p53I2 encoding the N-terminally truncated Δ40p53 isoform). The nucleotides forming G4s overlap the polymorphism rs17878362 (A1 wild-type allele, A2 16-base pair insertion)...

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PMID: 25269805
DOI: 10.1093/carcin/bgu206
PMCID: PMC4247521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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