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Article

Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements.

Nucleic acids research - 1 Jan 2011

Bandele Omari J, Wang Xuting, Campbell Michelle R, Pittman Gary S, Bell Douglas A

Abstract excerpt

p53 coordinates the expression of an intricate network of genes in response to stress signals. Sequence-specific DNA binding is essential for p53-mediated tumor suppression. We evaluated the impact of single-nucleotide polymorphisms (SNPs) in p53 response elements (p53RE) on DNA binding and gene expression in response to DNA damage. Using a bioinformatics approach based on incorporating p53 binding strength into...

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Identifiers

PMID: 20817676
DOI: 10.1093/nar/gkq764
PMCID: PMC3017610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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