Article
Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters.
Molecular cancer - 20 Oct 2006
Baumbusch Lars O, Myhre Simen, Langerød Anita, Bergamaschi Anna, Geisler Stephanie B, Lønning Per E, Deppert Wolfgang, Dornreiter Irene, Børresen-Dale Anne-Lise
Abstract excerpt
BACKGROUND: The tumor suppressor gene p53 (TP53) controls numerous signaling pathways and is frequently mutated in human cancers. Novel p53 isoforms suggest alternative splicing as a regulatory feature of p53 activity. RESULTS: In this study we have analyzed mRNA expression of both wild-type and mutated p53 and its respective Deltap53 isoform in 88 tumor samples from breast cancer in relation to clinical...
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