Article
PIN3 duplication may be partially responsible for TP53 haploinsufficiency.
BMC cancer - 15 Sept 2014
Winiecka-Klimek Marta, Szybka Malgorzata, Rieske Piotr, Piaskowski Sylwester, Bienkowski Michal, Walczak Maciej, Pacholczyk Marcin, Rostkowski Michal, Zieba Jolanta, Banaszczyk Mateusz, Hulas-Bigoszewska Krystyna, Peciak Joanna, Pawliczak Rafal, Stoczynska-Fidelus Ewelina
Abstract excerpt
BACKGROUND: Previously we have suggested that cancer cells develop a mechanism(s) which allows for either: silencing of the wild-type TP53 transcription, degradation of the wild-type TP53 mRNA, or selective overproduction of the mutated TP53 mRNA, which is the subject of this article. Sequencing of TP53 on the respective cDNA and DNA templates from tumor samples were found to give discordant results. DNA analysis...
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