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Article

DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.

Cell - 15 May 2009

Muñoz Manuel J, Pérez Santangelo M Soledad, Paronetto Maria P, de la Mata Manuel, Pelisch Federico, Boireau Stéphanie, Glover-Cutter Kira, Ben-Dov Claudia, Blaustein Matías, Lozano Juan J, Bird Gregory, Bentley David, Bertrand Edouard, Kornblihtt Alberto R

Abstract excerpt

DNA damage induces apoptosis and many apoptotic genes are regulated via alternative splicing (AS), but little is known about the control mechanisms. Here we show that ultraviolet irradiation (UV) affects cotranscriptional AS in a p53-independent way, through the hyperphosphorylation of RNA polymerase II carboxy-terminal domain (CTD) and a subsequent inhibition of transcriptional elongation, estimated in vivo and...

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Identifiers

PMID: 19450518
DOI: 10.1016/j.cell.2009.03.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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