Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response.

doi:10.1128/AAC.03337-14

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Article

Complex polymorphisms in the Plasmodium falciparum multidrug resistance protein 2 gene and its contribution to antimalarial response.

Antimicrobial agents and chemotherapy - 1 Dec 2014

Veiga Maria Isabel, Osório Nuno S, Ferreira Pedro Eduardo, Franzén Oscar, Dahlstrom Sabina, Lum J Koji, Nosten Francois, Gil José Pedro

Abstract excerpt

Plasmodium falciparum has the capacity to escape the actions of essentially all antimalarial drugs. ATP-binding cassette (ABC) transporter proteins are known to cause multidrug resistance in a large range of organisms, including the Apicomplexa parasites. P. falciparum genome analysis has revealed two genes coding for the multidrug resistance protein (MRP) type of ABC transporters: Pfmrp1, previously associated...

Topics

Amino Acid Sequence
Antimalarials
Artemisinins
Biological Transport
Chloroquine
Chromosomes
Drug Resistance, Multiple
Erythrocytes
Humans
INDEL Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Malaria, Falciparum

Mefloquine

Molecular Sequence Data

Multidrug Resistance-Associated Proteins

Parasitic Sensitivity Tests

Plasmodium falciparum

Polymorphism, Single Nucleotide

Quinolines

Source

Open in PubMed Open full text

Identifiers

PMID: 25267670
DOI: 10.1128/AAC.03337-14
PMCID: PMC4249497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25267670-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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