Article
In vitro sensitivities of Plasmodium falciparum isolates from the China-Myanmar border to piperaquine and association with polymorphisms in candidate genes.
Antimicrobial agents and chemotherapy - 1 Apr 2013
Hao Mingming, Jia Dandan, Li Qing, He Yongshu, Yuan Lili, Xu Shuhui, Chen Kexuan, Wu Jia, Shen Lijuan, Sun Lin, Zhao Hongbin, Yang Zhaoqing, Cui Liwang
Abstract excerpt
The recent reports of resistance in Plasmodium falciparum to artemisinin derivatives and their partner drugs demand intensive studies toward understanding the molecular mechanisms of resistance. In this study, we examined the in vitro susceptibility of 63 P. falciparum field isolates collected fr...
Topics
- Antimalarials
- Chloroquine
- Drug Resistance
- Humans
- Inhibitory Concentration 50
- Mutation
- Plasmodium falciparum
- Polymorphism, Genetic
- Protozoan Proteins
- Quinolines