Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance.

doi:10.1371/journal.pone.0020212

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Article

Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance.

PloS one - 1 Jan 2011

Veiga Maria Isabel, Ferreira Pedro Eduardo, Jörnhagen Louise, Malmberg Maja, Kone Aminatou, Schmidt Berit Aydin, Petzold Max, Björkman Anders, Nosten Francois, Gil Jose Pedro

Abstract excerpt

Chemotherapy is a critical component of malaria control. However, the most deadly malaria pathogen, Plasmodium falciparum, has repeatedly mounted resistance against a series of antimalarial drugs used in the last decades. Southeast Asia is an epicenter of emerging antimalarial drug resistance, including recent resistance to the artemisinins, the core component of all recommended antimalarial combination...

Topics

ATP-Binding Cassette Transporters
Animals
Antimalarials
Artemisinins
Base Sequence
Drug Resistance
Ethanolamines
Fluorenes
Gene Frequency
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Inhibitory Concentration 50

Lumefantrine

Malaria, Falciparum

Mefloquine

Membrane Transport Proteins

Multidrug Resistance-Associated Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21633513
DOI: 10.1371/journal.pone.0020212
PMCID: PMC3102103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21633513-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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