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Article

Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes.

Proceedings of the National Academy of Sciences of the United States of America - 16 Nov 2010

Dharia Neekesh V, Bright A Taylor, Westenberger Scott J, Barnes S Whitney, Batalov Serge, Kuhen Kelli, Borboa Rachel, Federe Glenn C, McClean Colleen M, Vinetz Joseph M, Neyra Victor, Llanos-Cuentas Alejandro, Barnwell John W, Walker John R, Winzeler Elizabeth A

Abstract excerpt

Plasmodium vivax causes 25-40% of malaria cases worldwide, yet research on this human malaria parasite has been neglected. Nevertheless, the recent publication of the P. vivax reference genome now allows genomics and systems biology approaches to be applied to this pathogen. We show here that whole-genome analysis of the parasite can be achieved directly from ex vivo-isolated parasites, without the need for in...

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Identifiers

PMID: 21037109
DOI: 10.1073/pnas.1003776107
PMCID: PMC2993397

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