Genetic polymorphisms of candidate markers and in vitro susceptibility of Plasmodium falciparum isolates from Thai-Myanmar border in relation to clinical response to artesunate-mefloquine combination.

doi:10.1016/j.actatropica.2014.06.015

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Article

Genetic polymorphisms of candidate markers and in vitro susceptibility of Plasmodium falciparum isolates from Thai-Myanmar border in relation to clinical response to artesunate-mefloquine combination.

Acta tropica - 1 Nov 2014

Phompradit Papichaya, Muhamad Poonuch, Chaijaroenkul Wanna, Na-Bangchang Kesara

Abstract excerpt

The genetic polymorphisms of the candidate markers of antimalarial drug resistance pfcrt, pfmdr1, pfatp6, and pfmrp1 were investigated in relationship with in vitro susceptibility of Plasmodium falciparum isolates and clinical response following artesunate (AS)-mefloquine (MQ) combination in 21 and 27 samples obtained from patients with recrudescence and adequate clinical response, respectively. MQ (21.0 vs....

Topics

Adolescent
Adult
Antimalarials
Artemisinins
Artesunate
Drug Resistance
Drug Therapy, Combination
Female
Gene Dosage
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Malaria, Falciparum

Male

Mefloquine

Middle Aged

Multidrug Resistance-Associated Proteins

Mutation

Myanmar

Source

Open in PubMed

Identifiers

PMID: 25004442
DOI: 10.1016/j.actatropica.2014.06.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25004442-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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