Article
Polymorphisms in Cytochrome P450 genes: implications for Plasmodium vivax malaria treatment in Brazil.
Transactions of the Royal Society of Tropical Medicine and Hygiene - 3 Mar 2026
Cerilo-Filho Marcelo, Almeida Maria Naely G, Sampaio Marrara P, Mello Amanda G N C, Fernando Dulce J V, Braz Raisa P, Miceli Leonardo A, Reis Nathália F, Guimarães Ricardo J de P, Silva José R S, Storti-Melo Luciane M, Baptista Andréa R S, Machado Ricardo L D
Abstract excerpt
Plasmodium vivax is the most prevalent malaria parasite in Brazil, accounting for approximately 85% of annual malaria cases. Therapeutic failure in malaria has been associated with host genetic factors that influence drug metabolism. This study aimed to evaluate the impact of Cytochrome P450 gene polymorphisms on the treatment of Plasmodium vivax malaria in Brazil. A systematic review was conducted following the...
Topics
- Humans
- Malaria, Vivax
- Brazil
- Antimalarials
- Plasmodium vivax
- Cytochrome P-450 Enzyme System
- Polymorphism, Single Nucleotide
- Cytochrome P-450 CYP2D6