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Article

Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa.

The Journal of infectious diseases - 1 Nov 2009

Dahlström Sabina, Ferreira Pedro E, Veiga M Isabel, Sedighi Nazli, Wiklund Lisa, Mårtensson Andreas, Färnert Anna, Sisowath Christin, Osório Lyda, Darban Hamid, Andersson Björn, Kaneko Akira, Conseil Gwenaëlle, Björkman Anders, Gil J Pedro

Abstract excerpt

Plasmodium falciparum response mechanisms to the major artemisinin-based combination therapies (ACTs) are largely unknown. Multidrug-resistance protein (MRP)-like adenosine triphosphate (ATP)-binding cassette transporters are known to be related to multidrug resistance in many organisms. Therefore, we hypothesized that sequence variation in pfmrp1 can contribute to decreased parasite sensitivity to ACT. Through...

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PMID: 19807279
DOI: 10.1086/606009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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