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Article

Frequency of TERT promoter mutations in primary tumors of the liver.

Virchows Archiv : an international journal of pathology - 1 Dec 2014

Quaas Alexander, Oldopp Theresa, Tharun Lars, Klingenfeld Catina, Krech Till, Sauter Guido, Grob Tobias J

Abstract excerpt

Transcriptional regulation of the TERT gene is a major cause of the cancer-specific increase in telomerase activity. Recently, frequent somatic mutations in the TERT promoter have been described in several tumor entities such as melanoma, glioblastoma, bladder cancer, and hepatocellular carcinoma. By generating a putative consensus binding site for ETS transcription factors within the TERT promoter, these...

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Source

Identifiers

PMID: 25267585
DOI: 10.1007/s00428-014-1658-7

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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