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Article

The TERT promoter mutation incidence is modified by germline TERT rs2736098 and rs2736100 polymorphisms in hepatocellular carcinoma.

Oncotarget - 4 Apr 2017

Yuan Xiaotian, Cheng Guanghui, Yu Jingya, Zheng Shunzhen, Sun Chao, Sun Qing, Li Kailin, Lin Zhaomin, Liu Tiantian, Li Ping, Xu Yiteng, Kong Feng, Bjorkholm Magnus, Xu Dawei

Abstract excerpt

Telomerase activation via induction of the catalytic component telomerase reverse transcriptase (TERT) plays essential roles in malignant transformation. TERT promoter-activating mutations were recently identified as a novel mechanism to activate telomerase in hepatocellular carcinoma (HCC) and many other malignancies. In addition, single nucleotide polymorphisms (SNPs) in the TERT rs2736098 and rs2736100 are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular
Share to Case-Control Studies
Share to Gene Frequency
Share to Germ-Line Mutation
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Share to Promoter Regions, Genetic
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Source

Open in PubMed Open full text

Identifiers

PMID: 28416747
DOI: 10.18632/oncotarget.15498
PMCID: PMC5410290

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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