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Article

TERT promoter mutation in resectable hepatocellular carcinomas: a strong association with hepatitis C infection and absence of hepatitis B infection.

International journal of surgery (London, England) - 1 Jan 2014

Chen Yu-Ling, Jeng Yung-Ming, Chang Chih-Ning, Lee Hsin-Jung, Hsu Hey-Chi, Lai Po-Lin, Yuan Ray-Hwang

Abstract excerpt

INTRODUCTION: Mutation in the core promoter of the telomerase reverse transcriptase (TERT) gene was determined to be a frequent event in malignant melanoma and other cancers. However, the role of TERT promoter mutation in hepatocellular carcinomas (HCCs) remains largely unknown. METHODS: Genomic DNA samples from the tumor tissue of 195 HCCs were analyzed for TERT promoter mutation at 2 hotspots (-124 and -146 bp...

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Topics

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Share to Promoter Regions, Genetic
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

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Share to Liver Neoplasms

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Source

Identifiers

PMID: 24866078
DOI: 10.1016/j.ijsu.2014.05.066

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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