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Frequency of somatic mutations in TERT promoter, TP53 and CTNNB1 genes in patients with hepatocellular carcinoma from Southern Italy

22 Jan 2020

Abstract excerpt

Somatic mutations in the TERT promoter and in the TP53 and CTNNB1 genes are considered drivers for hepatocellular carcinoma (HCC) development. They show variable frequencies in different geographic areas, possibly depending on liver disease etiology and environmental factors. TP53, CTNNB1 and TERT genetic mutations were investigated in tumor and non‑tumor liver tissues from 67 patients with HCC and liver tissue...

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Identifiers

PMID: 32194736
DOI: 10.3892/ol.2020.11332

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