Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of OPRM1 A118G variant with risk of morphine-induced respiratory depression following spine fusion in adolescents.

The pharmacogenomics journal - 1 Jun 2015

Chidambaran V, Mavi J, Esslinger H, Pilipenko V, Martin L J, Zhang K, Sadhasivam S

Abstract excerpt

The μ1 opioid receptor (OPRM1) genetic variant A118G results in decreased μ-receptor binding potential in the brain and increases morphine requirement. We hypothesized that OPRM1 A118G polymorphism will affect morphine-induced respiratory depression (MIRD) risk in children receiving morphine. A prospective genotype-blinded study was conducted in 88 healthy adolescents (11-18 years; 67% female, 85% Caucasian) who...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Morphine

Share to Receptors, Opioid, mu

Share to Respiratory Insufficiency

Share to Scoliosis

Source

Open in PubMed Open full text

Identifiers

PMID: 25266679
DOI: 10.1038/tpj.2014.59
PMCID: PMC4406866

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of OPRM1 A118G variant with risk of morphine-induced respiratory depression following spine fusion in adolescents.PMID 25266679Read ↗

Allele frequency and genotype distribution of the opioid receptor μ-1 (OPRM1) A118G polymorphism in the Western Saudi population.Semantic proximity Read ↗

Consequences of the 118A&gt;G polymorphism in the OPRM1 gene: translation from bench to bedside?Semantic proximity Read ↗

The OPRM1 A118G Polymorphism Revisited: Recent Developments and Implications for Personalized Treatment.Semantic proximity Read ↗

Genetic polymorphisms of OPRM1 on the efficacy and safety of anesthetic and analgesic agents: a systematic review.Semantic proximity Read ↗

OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.Semantic proximity Read ↗

µ-opioid receptor gene variant OPRM1 118 A>G: a summary of its molecular and clinical consequences for pain.Semantic proximity Read ↗

Pharmacogenomics of the human µ-opioid receptor.Semantic proximity Read ↗

OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis.Semantic proximity Read ↗

Comparison of the Effects of OPRM1 A118G Polymorphism Using Different Opioids: A Prospective Study.Semantic proximity Read ↗

Overview of genetic analysis of human opioid receptors.Semantic proximity Read ↗

The μ-opioid receptor gene polymorphism 118A>G weakens the pharmacological action of buprenorphine.Semantic proximity Read ↗

Overview of Genetic Analysis of Human Opioid Receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.