Article
Comparison of the Effects of OPRM1 A118G Polymorphism Using Different Opioids: A Prospective Study.
Journal of pain and symptom management - 1 Jan 2024
Takemura Miho, Niki Kazuyuki, Okamoto Yoshiaki, Kawamura Tomohiro, Kohno Makie, Matsuda Yoshinobu, Ikeda Kenji
Abstract excerpt
CONTEXT: μ-opioid receptor gene (OPRM1) A118G polymorphism (rs1799971) causes loss of N-glycosylation sites at the extracellular domain of μ-opioid receptors. G-allele carriers show a limited response to morphine; however, studies investigating the impact of A118G polymorphism on the efficacy of opioids other than morphine are limited. OBJECTIVE: To compare the impact of A118G polymorphism on the efficacy of...
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