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Article

Genome-wide interaction analysis reveals replicated epistatic effects on brain structure.

Neurobiology of aging - 1 Jan 2015

Hibar Derrek P, Stein Jason L, Jahanshad Neda, Kohannim Omid, Hua Xue, Toga Arthur W, McMahon Katie L, de Zubicaray Greig I, Martin Nicholas G, Wright Margaret J, Weiner Michael W, Thompson Paul M

Abstract excerpt

The discovery of several genes that affect the risk for Alzheimer's disease ignited a worldwide search for single-nucleotide polymorphisms (SNPs), common genetic variants that affect the brain. Genome-wide search of all possible SNP-SNP interactions is challenging and rarely attempted because of the complexity of conducting approximately 10(11) pairwise statistical tests. However, recent advances in machine...

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Identifiers

PMID: 25264344
DOI: 10.1016/j.neurobiolaging.2014.02.033
PMCID: PMC4332874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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