Article

Independent Genomic Sources of Brain Structure and Function

2021-01-07

Abstract excerpt

<h4>Introduction</h4> The last decade has seen a surge in well powered genome-wide association studies (GWASs) of complex behavioural traits, disorders, and more recently, of brain structural and functional neuroimaging features. However, the extreme polygenicity of these complex traits makes it difficult to translate the GWAS signal into mechanistic biological insights. We postulate that the covariance of SNP-ef...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 937ebcd1-6be7-5e03-97af-cfb49b664817
DOI: 10.1101/2021.01.06.425535

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Independent Genomic Sources of Brain Structure and FunctionDOI 10.1101/2021.01.06.425535Read

The Genetic Architecture of Brain Structure and Function: A Data-Driven Interpretation Using genomICASemantic proximity Read

Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic ArchitectureSemantic proximity Read

Transcriptome-wide association analysis of 211 neuroimaging traits identifies new genes for brain structures and yields insights into the gene-level pleiotropy with other complex traitsSemantic proximity Read

Integration of tissue-specific multi-omics data implicates brain targets for complex neuropsychiatric traitsSemantic proximity Read

Heritability of regional brain volumes in large-scale neuroimaging and genetic studiesSemantic proximity Read

Deciphering the genetic architecture of human brain structure and function: a brief survey on recent advances of neuroimaging genomics.Semantic proximity Read

Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic ArchitectureSemantic proximity Read

Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies.Semantic proximity Read

Deciphering cell type-specific causal genetic effects on brain imaging-derived phenotypes and disorders with single-cell Mendelian randomization.Semantic proximity Read

From variants to mechanisms: Neurogenomics in the post-GWAS era.Semantic proximity Read

Brain Catalog: a comprehensive resource for the genetic landscape of brain-related traits.Semantic proximity Read

Phenotype Discovery from Population Brain ImagingSemantic proximity Read