Article
Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects.
NeuroImage - 15 Jun 2011
Hibar Derrek P, Stein Jason L, Kohannim Omid, Jahanshad Neda, Saykin Andrew J, Shen Li, Kim Sungeun, Pankratz Nathan, Foroud Tatiana, Huentelman Matthew J, Potkin Steven G, Jack Clifford R, Weiner Michael W, Toga Arthur W, Thompson Paul M
Abstract excerpt
Imaging traits provide a powerful and biologically relevant substrate to examine the influence of genetics on the brain. Interest in genome-wide, brain-wide search for influential genetic variants is growing, but has mainly focused on univariate, SNP-based association tests. Moving to gene-based multivariate statistics, we can test the combined effect of multiple genetic variants in a single test statistic....
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